PF 06281355

Tocris Bioscience, part of Bio-Techne | Catalog # 6004

Selective myeloperoxidase (MPO) inhibitor
Discontinued Product
6004 has been discontinued. View all Other Oxidase/Oxygenase Compounds products.

Key Product Details

Description

Selective myeloperoxidase (MPO) inhibitor

View all Other Oxidase/Oxygenase Compounds »

Product Description

PF 06281355 is a selective myeloperoxidase (MPO) inhibitor (IC50 = 1.5 μM in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Product Specifications

Molecular Weight

321.35

Formula

C14H15N3O4S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide

CAS Number

1435467-38-1

PubChem ID

71568997

InChI Key

LJBUZOGABRDGBR-UHFFFAOYSA-N

SMILES

COC1=CC(C2=CC(NC(N2CC(N)=O)=S)=O)=C(C=C1)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.43 20 with gentle warming

Preparing Stock Solutions for PF 06281355

The following data is based on the product molecular weight 321.35

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.56 mL 77.80 mL 155.59 mL
1 mM 3.11 mL 15.56 mL 31.12 mL
2 mM 1.56 mL 7.78 mL 15.56 mL
10 mM 0.31 mL 1.56 mL 3.11 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Product Documents for PF 06281355

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 06281355

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.