PF 06260933 dihydrochloride

Name: PF 06260933 dihydrochloride
Brand: Tocris Bioscience
SKU: 5752

Tocris Bioscience, part of Bio-Techne | Catalog # 5752

Citations (2)

COA / SDS

MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK

Key Product Details

Description:	MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK
Chemical Name:	5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	369.68

View Full Technical Details for PF 06260933 dihydrochloride

Technical Data
Citations

Biological Activity for PF 06260933 dihydrochloride

PF 06260933 dihydrochloride is a MAP4K4 (HGK) inhibitor (IC₅₀ = 140 nM). Also inhibits MINK and TNIK (IC₅₀ values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 06260933 dihydrochloride

PF 06260933 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PF 06260933 dihydrochloride

M. Wt	369.68
Formula	C₁₆H₁₃ClN₄.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1883548-86-4
PubChem ID	118701007
InChi Key	VRQXEOPUAQLBQI-UHFFFAOYSA-N
Smiles	NC1=NC=C(C3=CN=C(N)C=C3)C=C1C2=CC=C(Cl)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 06260933 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	36.97	100
	DMSO	7.39	20

Preparing Stock Solutions for PF 06260933 dihydrochloride

The following data is based on the product molecular weight 369.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.71 mL	13.53 mL	27.05 mL
5 mM	0.54 mL	2.71 mL	5.41 mL
10 mM	0.27 mL	1.35 mL	2.71 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for PF 06260933 dihydrochloride

References are publications that support the biological activity of the product.

Ammirati Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment. ACS Med.Chem.Lett. 2015 PMID: 26617966