PF 05175157
Tocris Bioscience, part of Bio-Techne | Catalog # 5790
Potent acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor
Key Product Details
Description
Potent acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor
Product Description
PF 05175157 is an potent acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC50 values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
405.49
Formula
C23H27N5O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one
CAS Number
1301214-47-0
PubChem ID
52934180
InChI Key
BDXXSFOJPYSYOC-UHFFFAOYSA-N
SMILES
O=C(C4=CC=C(N=C(C)N5)C5=C4)N1CCC(CC(C=NN3C(C)C)=C3C(C2)=O)2CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.27 | 50 | |
| Ethanol | 8.11 | 20 |
Preparing Stock Solutions
for PF 05175157
The following data is based on the product molecular weight 405.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.93 mL | 24.66 mL | 49.32 mL |
| 2.5 mM | 0.99 mL | 4.93 mL | 9.86 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.93 mL |
| 25 mM | 0.10 mL | 0.49 mL | 0.99 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Griffith Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes. J.Med.Chem. 2014 PMID: 25423286
Product Specific Notices for PF 05175157
For research use only
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