Pexacerfont
Tocris Bioscience, part of Bio-Techne | Catalog # 6451
Potent and selective CRF1 antagonist; anxiolytic
Key Product Details
Description
Potent and selective CRF1 antagonist; anxiolytic
Product Description
Pexacerfont is a potent and selective corticotropin-releasing factor 1 receptor (CRF1) antagonist (IC50 = 6.1 nM). Displays >150 fold selectivity for CRF1 over CRF2b. Inhibits CRF-mediated adrenocorticotropic hormone (ACTH) release from pituitary cell culture (IC50 = 129 nM). Displays anxiolytic effects in rat behavioral paradigms.Product Specifications
Molecular Weight
340.43
Formula
C18H24N6O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine
CAS Number
459856-18-9
PubChem ID
9884366
InChI Key
LBWQSAZEYIZZCE-SNVBAGLBSA-N
SMILES
CC[C@H](NC1=NC(C)=NC2=C(C3=C(N=C(C=C3)OC)C)C(C)=NN12)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.04 | 100 | |
| Ethanol | 34.04 | 100 |
Preparing Stock Solutions
for Pexacerfont
The following data is based on the product molecular weight 340.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.94 mL | 14.69 mL | 29.37 mL |
| 5 mM | 0.59 mL | 2.94 mL | 5.87 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for Pexacerfont
For research use only
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