Perlapine
Tocris Bioscience, part of Bio-Techne | Catalog # 5549
Potent hM3Dq and hM4Di DREADD agonist in vitro
Key Product Details
Description
Potent hM3Dq and hM4Di DREADD agonist in vitro
Product Description
Perlapine is a potent muscarinic DREADD agonist (pEC50 values are 8.38, 8.08 and 7.27 for hM1Dq, hM3Dq and hM4Di in vitro, respectively). Exhibits >10,000-fold selectivity for hM3Dq over hM3 receptors.Product Specifications
Molecular Weight
291.39
Formula
C19H21N3
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
CAS Number
1977-11-3
PubChem ID
16106
InChI Key
PWRPUAKXMQAFCJ-UHFFFAOYSA-N
SMILES
CN(CC4)CCN4C1=NC(C=CC=C3)=C3CC2=C1C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.46 | 5 with gentle warming | |
| DMSO | 14.57 | 50 |
Preparing Stock Solutions
for Perlapine
The following data is based on the product molecular weight 291.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.86 mL | 34.32 mL | 68.64 mL |
| 2.5 mM | 1.37 mL | 6.86 mL | 13.73 mL |
| 5 mM | 0.69 mL | 3.43 mL | 6.86 mL |
| 25 mM | 0.14 mL | 0.69 mL | 1.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thompson DREADD agonist 21 (C21) is an effective agonist for muscarinic-based DREADDs in vitro and in vivo. ACS Pharmacol.Transl.Sci. 2018 PMID: 30868140
- Chen The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 2015 PMID: 25587888
Product Specific Notices for Perlapine
For research use only
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