Pentostatin
Tocris Bioscience, part of Bio-Techne | Catalog # 2033
Adenosine deaminase inhibitor
Key Product Details
Description
Adenosine deaminase inhibitor
Alternative Names
Deoxycoformycin
Product Description
Pentostatin is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.Product Specifications
Molecular Weight
268.27
Formula
C11H16N4O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
CAS Number
53910-25-1
PubChem ID
439693
InChI Key
FPVKHBSQESCIEP-JQCXWYLXSA-N
SMILES
O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CNC[C@H]3O)=C3N=C2)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.83 | 100 | |
| DMSO | 20.12 | 75 |
Preparing Stock Solutions
for Pentostatin
The following data is based on the product molecular weight 268.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.73 mL | 18.64 mL | 37.28 mL |
| 5 mM | 0.75 mL | 3.73 mL | 7.46 mL |
| 10 mM | 0.37 mL | 1.86 mL | 3.73 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nabhan Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res.
- Klohs and Kraker Pentostatin: future directions. Pharmacol.Rev. 1992 PMID: 1480666
Product Specific Notices for Pentostatin
For research use only
⚠ WARNING: This product can expose you to chemicals including Pentostatin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
Loading...
Loading...