PDEδ ATTEC 12C

Tocris Bioscience, part of Bio-Techne | Catalog # 8824

PDEδ autophagy-tethering compound (ATTEC) Degrader
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Key Product Details

Description

PDEδ autophagy-tethering compound (ATTEC) Degrader

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Product Description

PDEδ ATTEC 12C is a selective PDEδ autophagy-tethering compound (ATTEC) Degrader (DC50 = 1.7 μM; Dmax = 85%; Kd = 56 nM). Degrades PDEδ through lysosome-mediated autophagy. Inhibits proliferation of KRAS mutant Capan-1 and MiaPaCa-2 pancreatic cancer cells (IC50 values are 0.8 μM and 1.4 μM respectively); dose- and time-dependently induces apoptosis.

Product Specifications

Molecular Weight

999.54

Formula

C41H42Br2IN7O5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(6-(2-(2,6-Dibromo-4-((5-iodo-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamido)hexyl)-4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide

InChI Key

BYPQUTISFKWFMK-DXJNIWACSA-N

SMILES

BrC1=CC(/C=C2C(C=C(I)C=C3)=C3NC/2=O)=CC(Br)=C1OCC(NCCCCCCNC(CCCN4C(C5=NN(C6=CC=C(C)C=C6)C(C)=C5C(C)=N4)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.99 20

Preparing Stock Solutions for PDEδ ATTEC 12C

The following data is based on the product molecular weight 999.54

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 5.00 mL 25.01 mL 50.02 mL
1 mM 1.00 mL 5.00 mL 10.00 mL
2 mM 0.50 mL 2.50 mL 5.00 mL
10 mM 0.10 mL 0.50 mL 1.00 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PDEδ ATTEC 12C

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PDEδ ATTEC 12C

For research use only

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