PD 81723

Name: PD 81723
Brand: Tocris Bioscience
SKU: 1363

Tocris Bioscience, part of Bio-Techne | Catalog # 1363

Citations (1)

COA / SDS

Positive allosteric modulator of A1 receptors

Key Product Details

Description:	Positive allosteric modulator of A₁ receptors
Chemical Name:	(2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone
Purity:	≥98% (HPLC)
Molecular Weight:	299.31

View Full Technical Details for PD 81723

Technical Data
Citations

Biological Activity for PD 81723

PD 81723 is an allosteric potentiator at the adenosine A₁ receptor; acts via agonist-dependent and -independent mechanisms. Enhances agonist affinity for, and increased t_½ of dissociation from, the receptor. Also inhibits basal and forskolin-stimulated adenylyl cyclase (AC) activity in A₁ receptors expressed in CHO cells, possibly via direct potentiation of constitutive receptor activity or by direct inhibition of AC. Active in vivo.

Technical Data for PD 81723

M. Wt	299.31
Formula	C₁₄H₁₂F₃NOS
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	132861-87-1
PubChem ID	122028
InChi Key	KKDKAWKYGCUOGR-UHFFFAOYSA-N
Smiles	CC1=C(C)C(C(=O)C2=CC(=CC=C2)C(F)(F)F)=C(N)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 81723

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	29.93	100
	DMSO	29.93	100

Preparing Stock Solutions for PD 81723

The following data is based on the product molecular weight 299.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.34 mL	16.71 mL	33.41 mL
5 mM	0.67 mL	3.34 mL	6.68 mL
10 mM	0.33 mL	1.67 mL	3.34 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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References for PD 81723

References are publications that support the biological activity of the product.

Musser Adenosine A₁ receptor-dependent and -independent effects of the allosteric enhancer PD 81,723. J.Pharmacol.Exp.Ther. 1999 PMID: 9918544
Kollias-Baker Agonist-independent effect of an allosteric enhancer of the A₁ adenosine receptor in CHO cells stably expressing the recombinant human A₁ receptor. J.Pharmacol.Exp.Ther. 1997 PMID: 9152383
Mizumura PD 81,723, an allosteric enhancer of the A₁ adenosine receptor, lowers the threshold for ischemic preconditioning in dogs. Circ.Res. 1996 PMID: 8781475
Bruns Structure-activity relationships for enhancement of adenosine A₁ receptor binding by 2-amino-3-benzoylthiophenes. Mol.Pharmacol. 1990 PMID: 2250667