PD 334581
Tocris Bioscience, part of Bio-Techne | Catalog # 4824
MEK1 inhibitor
Product Description
PD 334581 is an inhibitor of MEK1. Analog of PD 184352 (Cat. No. 4237).Product Specifications
Molecular Weight
545.30
Formula
C20H19F3IN5O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[5-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-1,3,4-oxadiazol-2-yl]-4-morpholineethanamine
CAS Number
548756-68-9
PubChem ID
5287529
InChI Key
LZZYEMSEMRUPIM-UHFFFAOYSA-N
SMILES
FC1=CC(I)=CC=C1NC2=C(F)C(F)=CC=C2C3=NN=C(NCCN4CCOCC4)O3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.53 | 100 | |
| Ethanol | 5.45 | 10 |
Preparing Stock Solutions
for PD 334581
The following data is based on the product molecular weight 545.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.83 mL | 9.17 mL | 18.34 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.67 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.83 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ohren Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel competitive kinase inhibition. Nat.Struct.Mol.Biol. 2004 PMID: 15543157
- Zhang Targeting cancer with small molecule kinase inhibitors. Nat.Rev.Cancer 2009 PMID: 19104514
Product Specific Notices for PD 334581
For research use only
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