PD 168568 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3529
Potent and selective D4 antagonist
Key Product Details
Description
Potent and selective D4 antagonist
Product Description
PD 168568 dihydrochloride is a potent and selective dopamine D4 receptor antagonist (Ki values are 8.8 and 1842 nM at D4 and D2 receptors respectively). Reverses amphetamine-stimulated locomotion in vivo and is orally active.Product Specifications
Molecular Weight
422.39
Formula
C22H27N3O.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride
CAS Number
1782532-06-2
PubChem ID
56972231
InChI Key
RMNWLEGGYCVHFD-UHFFFAOYSA-N
SMILES
CC1=C(C)C=CC(N2CCN(CCC(N4)C3=CC=CC=C3C4=O)CC2)=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 21.12 | 50 | |
| DMSO | 42.24 | 100 |
Preparing Stock Solutions
for PD 168568 dihydrochloride
The following data is based on the product molecular weight 422.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.84 mL | 23.67 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.73 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Belliotti Isoindolinone enantiomers having affinity for the DA D4 receptor. Bioorg.Med.Chem.Lett. 1998 PMID: 9873377
Product Specific Notices for PD 168568 dihydrochloride
For research use only
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