PCI 34051
Tocris Bioscience, part of Bio-Techne | Catalog # 4643
Potent and selective HDAC8 inhibitor
Key Product Details
Description
Potent and selective HDAC8 inhibitor
Product Description
PCI 34051 is a potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias.Product Specifications
Molecular Weight
296.32
Formula
C17H16N2O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
CAS Number
950762-95-5
PubChem ID
24753719
InChI Key
AJRGHIGYPXNABY-UHFFFAOYSA-N
SMILES
O=C(NO)C1=CC=C2C(N(CC3=CC=C(OC)C=C3)C=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.63 | 100 | |
| 1eq. NaOH | 5.93 | 20 |
Preparing Stock Solutions
for PCI 34051
The following data is based on the product molecular weight 296.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.87 mL | 33.75 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Balasubramanian A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia 2008 PMID: 18256683
- Pipalia Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts. Proc.Natl.Acad.Sci.U.S.A. 2011 PMID: 21436030
Product Specific Notices for PCI 34051
For research use only
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