PB 28 dihydrochloride

Name: PB 28 dihydrochloride
Brand: Tocris Bioscience
SKU: 2562
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2562

(1)

Citations (7)

COA / SDS

High affinity σ2 agonist

Key Product Details

Description:	High affinity σ₂ agonist
Chemical Name:	1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	443.5

View Full Technical Details for PB 28 dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for PB 28 dihydrochloride

PB 28 dihydrochloride is a high affinity σ₂ receptor agonist (K_i values are 0.8 and 15.2 nM for σ₂ and σ₁ receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC₅₀ values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

Technical Data for PB 28 dihydrochloride

M. Wt	443.5
Formula	C₂₄H₃₈N₂O.2HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	172907-03-8
PubChem ID	46861545
InChi Key	DSRBJOQIBXACIV-UHFFFAOYSA-N
Smiles	COC1=CC=CC2=C1CCCC2CCCN3CCN(C4CCCCC4)CC3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PB 28 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	8.87	20 with gentle warming

Preparing Stock Solutions for PB 28 dihydrochloride

The following data is based on the product molecular weight 443.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.27 mL	56.37 mL	112.74 mL
1 mM	2.25 mL	11.27 mL	22.55 mL
2 mM	1.13 mL	5.64 mL	11.27 mL
10 mM	0.23 mL	1.13 mL	2.25 mL

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References for PB 28 dihydrochloride

References are publications that support the biological activity of the product.

Colabufo A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder. Naunyn-Schmied.Arch.Pharmacol.
Colabufo Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines. Naunyn-Schmied.Arch.Pharmacol.
Berardi New σ and 5-HT_1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives. J.Med.Chem. 1996 PMID: 8568804