Paxilline

Tocris Bioscience, part of Bio-Techne | Catalog # 2006

SERCA ATPase blocker. Also potent BKCa channel blocker
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2006/10
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Key Product Details

Description

SERCA ATPase blocker. Also potent BKCa channel blocker

View all Ca2+-ATPase Blockers »

Product Description

Paxilline is a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels. Binds to the α-subunit of BKCa (Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca2+-ATPase (IC50 = 5 - 50 μM).

Product Specifications

Molecular Weight

435.56

Formula

C27H33NO4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyranobenzindeno[1,2-b]indol-3(4bH)-one

CAS Number

57186-25-1

PubChem ID

105008

InChI Key

ACNHBCIZLNNLRS-UBGQALKQSA-N

SMILES

[H][C@@]4([C@](C)3[C@]5(C)[C@@](C([C@]6([H])CC5)=CC([C@@H]([C@](O)(C)C)O6)=O)(O)CC4)CC2=C3NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.56 100

Preparing Stock Solutions for Paxilline

The following data is based on the product molecular weight 435.56

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.30 mL 11.48 mL 22.96 mL
5 mM 0.46 mL 2.30 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.30 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Paxilline

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Paxilline

For research use only

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