Paroxetine maleate

Product Description

Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K_i = 0.05 nM). K_i values are 1.1, 350 and 1100 nM for inhibition of [³H]-5-HT, [³H]-l-NA and [³H]-DA uptake respectively. Displays minimal affinity for α₁-, α₂- or β-adrenoceptors, 5-HT_2A, 5-HT_1A, D₂ or H₁ receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K_i = 42 nM). Antidepressant and anxiolytic in vivo.

Solubility

Preparing Stock Solutions for Paroxetine maleate

The following data is based on the product molecular weight 445.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.22 mL	22.45 mL
5 mM	0.45 mL	2.24 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Fujishiro Comparison of the anticholin. effects of the serotonergic antidepressants, paroxetine, fluvox. and clomipramine. Eur.J.Pharmacol. 2002 PMID: 12421645
• Owens Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 1997 PMID: 9400006
• Bourin Paroxetine: a review. CNS Drug Rev. 2001 PMID: 11420571
• Thomas Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology 1987 PMID: 2962217