Pam2CSK4
Tocris Bioscience, part of Bio-Techne | Catalog # 4637
TLR2/6 agonist; induces TNF-α production
Key Product Details
Description
TLR2/6 agonist; induces TNF-α production
Product Description
Pam2CSK4 is a toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.Product Specifications
Molecular Weight
1271.83
Formula
C65H126N10O12S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
868247-72-7
PubChem ID
71457280
InChI Key
LJUIOEFZFQRWJG-GHYFRYPYSA-N
SMILES
[H]N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in 0.25% acetic acid |
Calculators
Molarity Calculator
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Background References
References are publications that support the biological activity of the product.
- Omueti Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J.Biol.Chem. 2005 PMID: 16129684
- Schromm Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J.Biol.Chem. 2007 PMID: 17308304
- Boeglin Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 2011 PMID: 21991317
Product Specific Notices for Pam2CSK4
For research use only
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