Paliperidone

Name: Paliperidone
Brand: Tocris Bioscience
SKU: 4493

Tocris Bioscience, part of Bio-Techne | Catalog # 4493

Citations (3)

COA / SDS

5-HT2A antagonist; also D2 antagonist; atypical antipsychotic

Key Product Details

Description:	5-HT_2A antagonist; also D₂ antagonist; atypical antipsychotic
Alternative Names:	9-Hydroxyrisperidone,9-OH-risperidone
Chemical Name:	3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	426.48

View Full Technical Details for Paliperidone

Technical Data
Citations

Biological Activity for Paliperidone

Paliperidone is an atypical antipsychotic; metabolite of risperidone (Cat. No. 2865). Exhibits high affinity for 5-HT_2A receptors (K_i = 0.4 nM for cloned human 5-HT_2A receptors). Also displays nanomolar affinity for human D₂ receptors.

Technical Data for Paliperidone

M. Wt	426.48
Formula	C₂₃H₂₇FN₄O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	144598-75-4
PubChem ID	115237
InChi Key	PMXMIIMHBWHSKN-UHFFFAOYSA-N
Smiles	FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(C(O)CCC5)N5C4=O)CC3)=NO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Paliperidone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.26	10

Preparing Stock Solutions for Paliperidone

The following data is based on the product molecular weight 426.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.45 mL	117.24 mL	234.48 mL
0.5 mM	4.69 mL	23.45 mL	46.90 mL
1 mM	2.34 mL	11.72 mL	23.45 mL
5 mM	0.47 mL	2.34 mL	4.69 mL

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References for Paliperidone

References are publications that support the biological activity of the product.

Dremencov Distinct electrophysiological effects of paliper. and risper. on the firing activity of rat serotonin and NE neurons. Psychopharmacology 2007 PMID: 17530476
Leysen Risperidone: a novel antipsychotic with balanced serotonin-DA antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 1994 PMID: 7520908
Schotte Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 1996 PMID: 8935801