Paliperidone

Tocris Bioscience, part of Bio-Techne | Catalog # 4493

5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
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Key Product Details

Description

5-HT2A antagonist; also D2 antagonist; atypical antipsychotic

Alternative Names

9-Hydroxyrisperidone,9-OH-risperidone

View all 5-HT2A Receptor Antagonists »

Product Description

Paliperidone is an atypical antipsychotic; metabolite of risperidone (Cat. No. 2865). Exhibits high affinity for 5-HT2A receptors (Ki = 0.4 nM for cloned human 5-HT2A receptors). Also displays nanomolar affinity for human D2 receptors.

Product Specifications

Molecular Weight

426.48

Formula

C23H27FN4O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

CAS Number

144598-75-4

PubChem ID

115237

InChI Key

PMXMIIMHBWHSKN-UHFFFAOYSA-N

SMILES

FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(C(O)CCC5)N5C4=O)CC3)=NO2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.26 10

Preparing Stock Solutions for Paliperidone

The following data is based on the product molecular weight 426.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.45 mL 117.24 mL 234.48 mL
0.5 mM 4.69 mL 23.45 mL 46.90 mL
1 mM 2.34 mL 11.72 mL 23.45 mL
5 mM 0.47 mL 2.34 mL 4.69 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Paliperidone

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Paliperidone

For research use only

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