PACMA 31
Tocris Bioscience, part of Bio-Techne | Catalog # 5116
Irreversible protein disulfide isomerase (PDI) inhibitor
Key Product Details
Description
Irreversible protein disulfide isomerase (PDI) inhibitor
Product Description
PACMA 31 is an irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.Product Specifications
Molecular Weight
430.47
Formula
C21H22N2O6S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester
CAS Number
1401089-31-3
PubChem ID
66555902
InChI Key
AHOOZADJPNUFOQ-UHFFFAOYSA-N
SMILES
O=C(C#C)N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C1=CC=C(OC)C=C1OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.05 | 100 |
Preparing Stock Solutions
for PACMA 31
The following data is based on the product molecular weight 430.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.62 mL | 23.23 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.65 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xu Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 22988091
- Ge Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 2013 PMID: 24070012
Product Specific Notices for PACMA 31
For research use only
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