PA 452

Tocris Bioscience, part of Bio-Techne | Catalog # 5086

RXR antagonist
Discontinued Product
5086 has been discontinued. View all Retinoid X Receptor Antagonists products.

Key Product Details

Description

RXR antagonist

View all Retinoid X Receptor Antagonists »

Product Description

PA 452 is an RXR antagonist (pA2 = 7.11). Triggers dissociation of RXR tetramers. Attenuates cell proliferation and induces apoptosis in MCF-7 breast cancer cells.

Product Specifications

Molecular Weight

439.59

Formula

C26H37N3O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[[3-(Hexyloxy)-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl]methylamino]-5-pyrimidinecarboxylic acid

CAS Number

457657-34-0

PubChem ID

9803242

InChI Key

JJUUTJCZMGZJDZ-UHFFFAOYSA-N

SMILES

CC1(C)C2=C(C=C(N(C3=NC=C(C(O)=O)C=N3)C)C(OCCCCCC)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.96 100
Ethanol 4.4 10

Preparing Stock Solutions for PA 452

The following data is based on the product molecular weight 439.59

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.37 mL 22.75 mL
5 mM 0.45 mL 2.27 mL 4.55 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for PA 452

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PA 452

For research use only

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