P1075

Name: P1075
Brand: Tocris Bioscience
SKU: 1355
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1355

(1)

Citations (13)

COA / SDS

Potent Kir6 (KATP) channel opener

Discontinued Product

1355 has been discontinued. View all Inward Rectifier Potassium Channel Activators products.

Key Product Details

Description:	Potent K_ir6 (K_ATP) channel opener
Chemical Name:	N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine
Purity:	≥99% (HPLC)
Molecular Weight:	231.3

View Full Technical Details for P1075

Technical Data
Citations / Reviews (1)

Biological Activity for P1075

P1075 is a potent K_ir6 (K_ATP) channel opener (EC₅₀ for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (K_d values are 17 and 3 nM respectively).

Technical Data for P1075

M. Wt	231.3
Formula	C₁₂H₁₇N₅
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	60559-98-0
PubChem ID	43345
InChi Key	HKZNADVVGXKQDL-UHFFFAOYSA-N
Smiles	CCC(C)(C)\N=C(/NC#N)NC1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for P1075

References are publications that support the biological activity of the product.

Higdon Tissue and species variation in the vascular receptor binding of ³H-P1075, a potent K_ATP opener vasodilator. J.Pharmacol.Exp.Ther. 1997 PMID: 8996204
Buckner Pharmacological and molecular analysis of ATP-sensitive K⁺ channels in the pig and human detrusor. Eur.J.Pharmacol. 2000 PMID: 10988346
Gross Stoichiometry of potassium channel opener action. Mol.Pharmacol. 1999 PMID: 10570067
Ashcroft and Gribble New windows on the mechanism of action of K_ATP channel openers. TiPS 2000 PMID: 11121575

P1075

Tocris Bioscience, part of Bio-Techne | Catalog # 1355

Key Product Details

Biological Activity for P1075

Technical Data for P1075

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for P1075

Product Documents for P1075

COA

Certificate of Analysis

SDS

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