Ozagrel hydrochloride is a potent and selective inhibitor of thromboxane (TXA₂) synthetase (IC₅₀ = 4 nM). Does not inhibit prostacyclin (PGI₂) synthetase, cyclooxygenase or PGE₂ isomerase (IC₅₀ > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.

Product Specifications

Molecular Weight

264.71

Formula

C₁₃H₁₂N₂O₂.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride

CAS Number

78712-43-3

PubChem ID

6438130

InChI Key

CWKFWBJJNNPGAM-IPZCTEOASA-N

SMILES

Cl[H].OC(=O)\C=C\C1=CC=C(CN2C=CN=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	26.47	100

Preparing Stock Solutions for Ozagrel hydrochloride

The following data is based on the product molecular weight 264.71

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.78 mL	18.89 mL	37.78 mL
5 mM	0.76 mL	3.78 mL	7.56 mL
10 mM	0.38 mL	1.89 mL	3.78 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

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Background References

References are publications that support the biological activity of the product.

Naito Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets. Eur.J.Pharmacol. 1983 PMID: 6413227
Shinagawa Participation of thromboxane A₂ in the cough response in guinea-pigs: antitussive effect of ozagrel. Br.J.Pharmacol. 2000 PMID: 10991919
Hiraku Pharmacological studies on the TXA₂ synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jpn.J.Pharmacol. 1986 PMID: 3093741

Ozagrel hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1510

Key Product Details

Description

Alternative Names

View all Additional Prostanoid Receptor Compounds »

Product Description