OSU 03012

Tocris Bioscience, part of Bio-Techne | Catalog # 5682

PDPK1 (PDK1) inhibitor; inhibits Akt signaling
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Key Product Details

Description

PDPK1 (PDK1) inhibitor; inhibits Akt signaling

View all PDK-1 Inhibitors »

Product Description

OSU 03012 is a PDPK1 (PDK1) inhibitor; inhibits Akt signaling. Induces apoptosis of PC-3 and medulloblastoma cells, and inhibits growth of a number of tumor cell lines. Sensitizes radiotherapy-induced cell death and enhances cytotoxic effects of chemotherapeutic agents in vitro. Attenuates tumor growth of medulloblastoma xenografts in mice.

Product Specifications

Molecular Weight

460.45

Formula

C26H19F3N4O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide

CAS Number

742112-33-0

PubChem ID

10027278

InChI Key

YULUCECVQOCQFQ-UHFFFAOYSA-N

SMILES

O=C(CN)NC(C=C1)=CC=C1N2C(C(C=C3)=CC4=C3C5=CC=CC=C5C=C4)=CC(C(F)(F)F)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.05 100

Preparing Stock Solutions for OSU 03012

The following data is based on the product molecular weight 460.45

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.86 mL 21.72 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.09 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Product Documents for OSU 03012

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for OSU 03012

For research use only

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