OptoBI-1

Name: OptoBI-1
Brand: Tocris Bioscience
SKU: 7013

Tocris Bioscience, part of Bio-Techne | Catalog # 7013

Citations (1)

COA / SDS

Photoswitchable TRPC3/6/7 agonist

Discontinued Product

7013 has been discontinued. View all TRPC Channel Activators products.

Key Product Details

Description:	Photoswitchable TRPC3/6/7 agonist
Chemical Name:	1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	523.67

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Technical Data
Citations

Biological Activity for OptoBI-1

OptoBI-1 is a photoswitchable TRPC3/6/7 agonist (EC₅₀ for active cis-form ~0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ~ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.

Technical Data for OptoBI-1

M. Wt	523.67
Formula	C₃₂H₃₇N₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2415272-11-4
InChi Key	LUASQYYRQCWOMA-XAHDOWKMSA-N
Smiles	CCCCC1=CC=C(/N=N/C2=CC=C(C=C2)CCCC(N3CCC(N4C(NC5=CC=CC=C45)=O)CC3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for OptoBI-1

References are publications that support the biological activity of the product.

Lichtenegger An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel. Nat.Chem.Biol. 2018 PMID: 29556099
Curcic Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions. Pharmacol.Ther. 2019 PMID: 30974125
Curcic TRPC-mediated Ca²⁺ signaling and control of cellular functions. Semin.Cell Dev.Biol. 2019 PMID: 30738858
Tiapko Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem.Sci.

OptoBI-1

Tocris Bioscience, part of Bio-Techne | Catalog # 7013

Key Product Details

Biological Activity for OptoBI-1

Technical Data for OptoBI-1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for OptoBI-1

Product Documents for OptoBI-1

COA

Certificate of Analysis

SDS

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