Ondansetron hydrochloride

Product Description

Ondansetron hydrochloride is a selective 5-HT₃ receptor antagonist (K_i = 6.16 nM). Also an inhibitor of human multidrug and toxin extrusion (MATE) transporter 1 (IC₅₀ = <10-160 nM). Ondansetron blocks 5-HT-evoked transient inward currents (IC₅₀ = 0.1 nM) in human recombinant h5-HT_3A receptors. In an animal model of Parkinson's disease, Ondansetron reduces both the severity of dyskinesia and psychosis-like behaviors. Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.

Solubility

Preparing Stock Solutions for Ondansetron hydrochloride

The following data is based on the product molecular weight 329.83

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.03 mL	15.16 mL	30.32 mL
5 mM	0.61 mL	3.03 mL	6.06 mL
10 mM	0.30 mL	1.52 mL	3.03 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kwan Selective blockade of the 5-HT₃ receptor acutely alleviates dyskinesia and psychosis in the parkinsonian marmoset. Neuropharmacology 2021 PMID: 33152452
• Brown Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J.Physiol. 1998 PMID: 9508827
• Wittwer Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J.Med.Chem. 2013 PMID: 23241029
• Ginawi Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice. Pharmacol.Res. 2005 PMID: 15661576
• Ye Ondansetron: a selective 5-HT₃ receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 2001 PMID: 11474424
• Youssefyeh Development of high-affinity 5-HT₃ receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. J.Med.Chem. 1992 PMID: 1312602