Oncrasin 1

Name: Oncrasin 1
Brand: Tocris Bioscience
SKU: 3427

Tocris Bioscience, part of Bio-Techne | Catalog # 3427

Citations (3)

COA / SDS

Induces abnormal nuclear aggregation of PKCι; proapoptotic

Discontinued Product

3427 has been discontinued. View all Additional Protein Kinase C Compounds products.

Key Product Details

Description:	Induces abnormal nuclear aggregation of PKCι; proapoptotic
Chemical Name:	1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
Purity:	≥98% (HPLC)
Molecular Weight:	269.73

View Full Technical Details for Oncrasin 1

Technical Data
Citations

Biological Activity for Oncrasin 1

Oncrasin 1 is a proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC₅₀ ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.

Technical Data for Oncrasin 1

M. Wt	269.73
Formula	C₁₆H₁₂ClNO
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	75629-57-1
PubChem ID	872445
InChi Key	ZDRQMXCSSAPUMM-UHFFFAOYSA-N
Smiles	O=CC2=CN(CC3=CC=C(Cl)C=C3)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Oncrasin 1

References are publications that support the biological activity of the product.

Guo Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota. Cancer Res.
Guo Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol.Cancer Ther. 2009 PMID: 19208825

Oncrasin 1

Tocris Bioscience, part of Bio-Techne | Catalog # 3427

Key Product Details

Biological Activity for Oncrasin 1

Technical Data for Oncrasin 1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Oncrasin 1

Product Documents for Oncrasin 1

COA

Certificate of Analysis

SDS

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