Olopatadine hydrochloride

Name: Olopatadine hydrochloride
Brand: Tocris Bioscience
SKU: 4241

Tocris Bioscience, part of Bio-Techne | Catalog # 4241

Citations (4)

COA / SDS

H1 antagonist; ocular antiallergic agent

Key Product Details

Description:	H₁ antagonist; ocular antiallergic agent
Chemical Name:	(Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	373.87

View Full Technical Details for Olopatadine hydrochloride

Technical Data
Citations

Biological Activity for Olopatadine hydrochloride

Olopatadine hydrochloride is a histamine H₁ receptor antagonist (K_i = 31.6 nM). Inhibits the release of histamine, prostaglandin D₂ and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

Compound Libraries for Olopatadine hydrochloride

Olopatadine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Olopatadine hydrochloride

M. Wt	373.87
Formula	C₂₁H₂₃NO₃.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	140462-76-6
PubChem ID	5282402
InChi Key	HVRLZEKDTUEKQH-NOILCQHBSA-N
Smiles	O=C(CC(C=C3)=CC/1=C3OCC(C=CC=C2)=C2C1=C\CCN(C)C)O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Olopatadine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	28.04	75
	DMSO	37.39	100

Preparing Stock Solutions for Olopatadine hydrochloride

The following data is based on the product molecular weight 373.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.37 mL	26.75 mL
5 mM	0.53 mL	2.67 mL	5.35 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for Olopatadine hydrochloride

References are publications that support the biological activity of the product.

Sharif Characterization of the ocular antiallergic and antihistaminic effects of olopatidine (AL-4943A), a novel drug for treating ocular allergic diseases. J.Pharmacol.Exp.Ther. 1996 PMID: 8819509
Tamura Olopatidine ameliorates rat experimental cutaneous inflammation by improving skin barrier function. Pharmacology 2007 PMID: 17962722