Olanzapine

Tocris Bioscience, part of Bio-Techne | Catalog # 4349

5-HT2A antagonist; also D2 antagonist; atypical antipsychotic
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Key Product Details

Description

5-HT2A antagonist; also D2 antagonist; atypical antipsychotic

View all Non-selective 5-HT2 Receptor Antagonists »

Product Description

Olanzapine is an antagonist of 5-HT2A and dopamine D2 receptors (Ki values are 4 and 11 nM respectively). Also displays affinity for a range of other receptors including D1 and D4, 5-HT2C, α1, H1 and M1-4 receptors (Ki values range between 1.9 and 31 nM) . Atypical antipsychotic. Displays anticholinergic properties. Also a highly potent activator of hM4Di DREADDs (EC50 values are 5 nM in vitro and 7 nM in vivo).

Product Specifications

Molecular Weight

312.43

Formula

C17H20N4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

CAS Number

132539-06-1

PubChem ID

4585

InChI Key

WXPNDRBBWZMPQG-UHFFFAOYSA-N

SMILES

CC4=CC2=C(S4)NC1=CC=CC=C1N=C2N3CCN(C)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.24 100

Preparing Stock Solutions for Olanzapine

The following data is based on the product molecular weight 312.43

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.20 mL 16.00 mL 32.01 mL
5 mM 0.64 mL 3.20 mL 6.40 mL
10 mM 0.32 mL 1.60 mL 3.20 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Olanzapine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Olanzapine

For research use only

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