OGT 2115
Tocris Bioscience, part of Bio-Techne | Catalog # 2710
Antiangiogenic. Heparanase inhibitor
Key Product Details
Description
Antiangiogenic. Heparanase inhibitor
Product Description
OGT 2115 is a heparanase inhibitor (IC50 = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC50 > 30 μM). Exhibits antiangiogenic properties in vitro (IC50 = 1 μM).Product Specifications
Molecular Weight
495.30
Formula
C24H16BrFN2O4
Storage
Store at RT
Purity
≥97% (HPLC)
Chemical Name
2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid
CAS Number
853929-59-6
PubChem ID
44402523
InChI Key
LKBXWNYXDMSFQU-ONNFQVAWSA-N
SMILES
O=C(/C=C/C4=CC=C(Br)C=C4)NC(C(F)=C3)=CC=C3C2=NC1=CC(CC(O)=O)=CC=C1O2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.95 | 10 |
Preparing Stock Solutions
for OGT 2115
The following data is based on the product molecular weight 495.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.19 mL | 100.95 mL | 201.90 mL |
| 0.5 mM | 4.04 mL | 20.19 mL | 40.38 mL |
| 1 mM | 2.02 mL | 10.09 mL | 20.19 mL |
| 5 mM | 0.40 mL | 2.02 mL | 4.04 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Courtney Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor. Bioorg.Med.Chem.Letts.
- McKenzie Heparanase: a target for drug discovery in cancer and inflammation. Br.J.Pharmacol. 2007 PMID: 17339837
Product Specific Notices for OGT 2115
For research use only
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