ODQ

Name: ODQ
Brand: Tocris Bioscience
SKU: 0880

Tocris Bioscience, part of Bio-Techne | Catalog # 0880

Citations (83)

COA / SDS

Selective inhibitor of NO-sensitive guanylyl cyclase

Key Product Details

Description:	Selective inhibitor of NO-sensitive guanylyl cyclase
Chemical Name:	1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	187.16

View Full Technical Details for ODQ

Technical Data
Citations

Biological Activity for ODQ

ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase.

Compound Libraries for ODQ

ODQ is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ODQ

M. Wt	187.16
Formula	C₉H₅N₃O₂
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	41443-28-1
PubChem ID	1456
InChi Key	LZMHWZHOZLVYDL-UHFFFAOYSA-N
Smiles	O=C1ON=C2C=NC3=C(C=CC=C3)N12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ODQ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	3.74	20 with gentle warming
	DMSO	18.72	100

Preparing Stock Solutions for ODQ

The following data is based on the product molecular weight 187.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.34 mL	26.72 mL	53.43 mL
5 mM	1.07 mL	5.34 mL	10.69 mL
10 mM	0.53 mL	2.67 mL	5.34 mL
50 mM	0.11 mL	0.53 mL	1.07 mL

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Reconstitution Calculator

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References for ODQ

References are publications that support the biological activity of the product.

Hwang Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. Br.J.Pharmacol. 1998 PMID: 9863642
Fedele In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br.J.Pharmacol. 1996 PMID: 8894183
Garthwaite Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol.Pharmacol. 1995 PMID: 7544433
Boulton Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase. Neuroscience 1995 PMID: 8596640

ODQ