Obatoclax mesylate
Tocris Bioscience, part of Bio-Techne | Catalog # 6539
Inhibitor of Bcl-2 family members; antiapoptotic
Key Product Details
Description
Inhibitor of Bcl-2 family members; antiapoptotic
Alternative Names
GX15-070
Product Description
Obatoclax mesylate is an inhibitor of Bcl-2 family members (IC50 values are 1.11 - 7 μM). Inhibits the interaction of a BH3 domain peptide with 6 members of the Bcl-2 family (Bcl-2, Bcl-XL, Mcl-1, Bcl-W, A1, and Bcl-B) in vitro. Has antiapoptotic and antitumor effects in several tumor bearing mouse models.Product Specifications
Molecular Weight
413.49
Formula
C20H19N3O.CH3SO3H
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
CAS Number
803712-79-0
PubChem ID
16681698
InChI Key
ZVAGBRFUYHSUHA-LZOXOEDVSA-N
SMILES
CS(O)(=O)=O.COC1=CC(C2=CC3=CC=CC=C3N2)=N/C1=C/C4=C(C=C(N4)C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.67 | 50 |
Preparing Stock Solutions
for Obatoclax mesylate
The following data is based on the product molecular weight 413.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.84 mL | 24.18 mL | 48.37 mL |
| 2.5 mM | 0.97 mL | 4.84 mL | 9.67 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.84 mL |
| 25 mM | 0.10 mL | 0.48 mL | 0.97 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhai Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ. 2006 PMID: 16645636
- Nguyen Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc.Natl.Acad.Sci.U.S.A. 2007 PMID: 18040043
Product Specific Notices for Obatoclax mesylate
For research use only
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