OB 24 hydrochloride

Name: OB 24 hydrochloride
Brand: Tocris Bioscience
SKU: 6119

Tocris Bioscience, part of Bio-Techne | Catalog # 6119

Citations (6)

COA / SDS

Potent and selective heme oxygenase 1 (HO-1) inhibitor

Key Product Details

Description:	Potent and selective heme oxygenase 1 (HO-1) inhibitor
Chemical Name:	1-[[2-[2-(4-Bromophenyl)ethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazole hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	373.67

View Full Technical Details for OB 24 hydrochloride

Technical Data
Citations

Biological Activity for OB 24 hydrochloride

OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC₅₀ values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferation in vitro and PCA tumor growth and lymph node/lung metastases in vivo. Synergizes with Taxol (Cat. No. 1097).

Compound Libraries for OB 24 hydrochloride

OB 24 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for OB 24 hydrochloride

M. Wt	373.67
Formula	C₁₅H₁₇BrN₂O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	939825-12-4
PubChem ID	45265865
InChi Key	YSOWYXRHOAXXTG-UHFFFAOYSA-N
Smiles	BrC1=CC=C(C=C1)CCC2(OCCO2)CN3C=CN=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OB 24 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	37.4	100
	DMSO	37.37	100

Preparing Stock Solutions for OB 24 hydrochloride

The following data is based on the product molecular weight 373.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.38 mL	26.76 mL
5 mM	0.54 mL	2.68 mL	5.35 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for OB 24 hydrochloride

References are publications that support the biological activity of the product.

Alaoui-Jamali A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 2009 PMID: 19808972