NX 1607

Name: NX 1607
Brand: Tocris Bioscience
SKU: 8950

Tocris Bioscience, part of Bio-Techne | Catalog # 8950

COA / SDS

CBL-B intramolecular glue inhibitor

Key Product Details

Description:	CBL-B intramolecular glue inhibitor
Chemical Name:	2,3-Dihydro-2-[3-[cis-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-6-[[(3S)-3-methyl-1-piperidinyl]methyl]-4-(trifluoromethyl)-1H-isoindol-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	537.63

View Full Technical Details for NX 1607

Technical Data
Citations

Biological Activity for NX 1607

NX 1607 (Cbl-b-IN-3) is an inhibitor of CBL-B (Casitas B-lineage lymphoma proto-oncogene B), a RING-type E3 ubiquitin ligase. NX 1607 acts as an intramolecular glue. In vitro, NX 1607 activates MAPK/ERK signaling pathway and enhances T-cell activation in primary T cells and Jurkat T cells. In vivo, NX 1607 decreases tumor growth in cell lymphoma models. NX 1607 is orally bioavailable.

Licensing Information

Sold under license from Nurix Therapeutics

Technical Data for NX 1607

M. Wt	537.63
Formula	C₃₀H₃₄F₃N₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2573775-59-2
PubChem ID	155449671
InChi Key	HUOLMBXGHHSYHC-QWQFASRJSA-N
Smiles	CN1C([C@@]2(C3=CC(N4CC5=C(C(F)(F)F)C=C(CN6C[C@H](CCC6)C)C=C5C4=O)=CC=C3)C[C@H](C2)C)=NN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NX 1607

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	10.75	20
	ethanol	53.76	100

Preparing Stock Solutions for NX 1607

The following data is based on the product molecular weight 537.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.30 mL	18.60 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for NX 1607

References are publications that support the biological activity of the product.

Zhu Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation. J.Immunother.Cancer 2025 PMID: 40447319