NVS-STG2
Tocris Bioscience, part of Bio-Techne | Catalog # 8120
STING agonist, molecular glue that causes oligomerization of STING
Key Product Details
Description
STING agonist, molecular glue that causes oligomerization of STING
Product Description
NVS-STG2 is a STING agonist. It induces oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, acting as a molecular glue. NVS-STG2 elicits potent STING-mediated immune responses in cells and produces antitumor activities in hSTING knock-in mice.Product Specifications
Molecular Weight
427.54
Formula
C25H33NO5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid
CAS Number
3030588-01-0
PubChem ID
168719774
InChI Key
CZSPKEVHLRWAFC-UHFFFAOYSA-N
SMILES
OC(C1=CC=C(C(OC)=C1)NCC2=CC=C(C=C2)C3(OCC(C)(CO3)C)C(C)(C)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.75 | 100 |
Preparing Stock Solutions
for NVS-STG2
The following data is based on the product molecular weight 427.54
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.69 mL | 23.39 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol. 2024 PMID: 37828400
Product Specific Notices for NVS-STG2
For research use only
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