NVS PAK1 C
Tocris Bioscience, part of Bio-Techne | Catalog # 6133
Negative control of NVS PAK1 1 (Cat. No. 6132)
Key Product Details
Description
Negative control of NVS PAK1 1 (Cat. No. 6132)
Product Description
NVS PAK1 C is a negative control of NVS PAK1 1 (Cat. No. 6132), a potent and selective PAK1 inhibitor.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS PAK1 1 probe summary on the SGC website.Product Specifications
Molecular Weight
465.91
Formula
C22H23ClF3N5O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide
CAS Number
2250019-95-3
PubChem ID
136590564
InChI Key
RVHZFZVJXGIAJF-HNNXBMFYSA-N
SMILES
FC(F)CN(C(C=CC(F)=C1)=C1N=C2N[C@H]3CCN(C(N(C)C)=O)C3)C4=C2C=C(Cl)C=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.59 | 100 | |
| Ethanol | 9.32 | 20 |
Preparing Stock Solutions
for NVS PAK1 C
The following data is based on the product molecular weight 465.91
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.73 mL | 21.46 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.29 mL |
| 10 mM | 0.21 mL | 1.07 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Karpov Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor. ACS Med.Chem.Lett 2015 PMID: 26191365
Product Specific Notices for NVS PAK1 C
For research use only
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