NVP CXCR2 20

Name: NVP CXCR2 20
Brand: Tocris Bioscience
SKU: 5660

Tocris Bioscience, part of Bio-Techne | Catalog # 5660

COA / SDS

Potent and selective CXCR2 antagonist

Discontinued Product

5660 has been discontinued. View all Chemokine Receptor Antagonists products.

Key Product Details

Description:	Potent and selective CXCR2 antagonist
Chemical Name:	4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	319.33

View Full Technical Details for NVP CXCR2 20

Technical Data
Citations

Biological Activity for NVP CXCR2 20

Potent and selective CXCR2 antagonist (IC₅₀ = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.

Compound Libraries for NVP CXCR2 20

NVP CXCR2 20 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NVP CXCR2 20

M. Wt	319.33
Formula	C₁₅H₁₁F₂N₃OS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1029521-30-9
PubChem ID	24955240
InChi Key	PHHZYKZFEBRXAL-UHFFFAOYSA-N
Smiles	OC1=C(C#N)C(C2CC2)=NC(SCC3=CC=CC(F)=C3F)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NVP CXCR2 20

References are publications that support the biological activity of the product.

Porter The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists. Bioorg.Med.Chem.Lett. 2014 PMID: 24974342