NVP 231

Name: NVP 231
Brand: Tocris Bioscience
SKU: 3960

Tocris Bioscience, part of Bio-Techne | Catalog # 3960

Citations (9)

COA / SDS

Potent, selective and reversible CerK inhibitor

Key Product Details

Description:	Potent, selective and reversible CerK inhibitor
Chemical Name:	N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	431.55

View Full Technical Details for NVP 231

Technical Data
Citations

Biological Activity for NVP 231

NVP 231 is a potent, selective and reversible ceramide kinase (CerK) inhibitor (IC₅₀ = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC₅₀ ≥100 μM) and other lipid kinases.

Compound Libraries for NVP 231

NVP 231 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NVP 231

M. Wt	431.55
Formula	C₂₅H₂₅N₃O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	362003-83-6
PubChem ID	4096211
InChi Key	MVSSJPGNLQPWSW-UHFFFAOYSA-N
Smiles	O=C(C3=CC=CC=C3)NC2=NC(C=C1)=C(S2)C=C1NC(C45CC(C6)CC(CC6C5)C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NVP 231

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.16	100
	ethanol	2.16	5

Preparing Stock Solutions for NVP 231

The following data is based on the product molecular weight 431.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.59 mL	23.17 mL
5 mM	0.46 mL	2.32 mL	4.63 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for NVP 231

References are publications that support the biological activity of the product.

Niwa Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. Microvasc.Res. 2009 PMID: 19323974
Graf Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol.Pharmacol. 2009 PMID: 18612076
Graf A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. Anal.Biochem. 2009 PMID: 18831956