NU 7441
Tocris Bioscience, part of Bio-Techne | Catalog # 3712
Potent and selective DNA-PK inhibitor
Key Product Details
Description
Potent and selective DNA-PK inhibitor
Alternative Names
KU 57788
Product Description
NU 7441 is a potent and selective DNA-PK inhibitor (IC50 = 14 nM). Selective for DNA-PK over a range of kinases including mTOR, PI 3-K, ATM and ATR. Potentiates the effects of doxorubicin (Cat. No. 2252) and etoposide (Cat. No. 1226) in vitro and etoposide in vivo. Also enhances CRISPR-Cas9-mediated homology-directed repair (HDR) efficiency 2 to 3-fold, and decreases nonhomologous end-joining (NHEJ) frequency ~40%.Product Specifications
Molecular Weight
413.49
Formula
C25H19NO3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
CAS Number
503468-95-9
PubChem ID
11327430
InChI Key
JAMULYFATHSZJM-UHFFFAOYSA-N
SMILES
O=C1C3=C(C(C4=CC=CC5=C4SC6=C5C=CC=C6)=CC=C3)OC(N2CCOCC2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.07 | 5 with gentle warming |
Preparing Stock Solutions
for NU 7441
The following data is based on the product molecular weight 413.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 48.37 mL | 241.84 mL | 483.69 mL |
| 0.25 mM | 9.67 mL | 48.37 mL | 96.74 mL |
| 0.5 mM | 4.84 mL | 24.18 mL | 48.37 mL |
| 2.5 mM | 0.97 mL | 4.84 mL | 9.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Robert Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing. Genome Med. 2015 PMID: 26307031
- Willmore DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clin.Cancer Res. 2008 PMID: 18559621
- Leahy Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg.Med.Chem.Lett. 2004 PMID: 15546735
- Zhao Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res. 2006 PMID: 16707462
Product Specific Notices for NU 7441
For research use only
Loading...
Loading...
Loading...