NSC 668036

Name: NSC 668036
Brand: Tocris Bioscience
SKU: 5813

Tocris Bioscience, part of Bio-Techne | Catalog # 5813

Citations (10)

COA / SDS

Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein

Key Product Details

Description:	Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein
Chemical Name:	N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	460.52

View Full Technical Details for NSC 668036

Technical Data
Citations

Biological Activity for NSC 668036

NSC 668036 is a Wnt signaling inhibitor. Binds the PDZ domain of the Dishevelled (Dvl) protein. Inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Reduces severity of pulmonary fibrosis in a mouse model.

Compound Libraries for NSC 668036

NSC 668036 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for NSC 668036

M. Wt	460.52
Formula	C₂₁H₃₆N₂O₉
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	144678-63-7
PubChem ID	71312060
InChi Key	IPICFSFUAKDZEI-AJNGGQMLSA-N
Smiles	CC([C@@H](C(O)=O)OC([C@@H](NC([C@H](C(C)C)OC([C@@H](NC(OC(C)(C)C)=O)C)=O)=O)C)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 668036

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.05	100
	ethanol	46.05	100

Preparing Stock Solutions for NSC 668036

The following data is based on the product molecular weight 460.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.86 mL	21.71 mL
5 mM	0.43 mL	2.17 mL	4.34 mL
10 mM	0.22 mL	1.09 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for NSC 668036

References are publications that support the biological activity of the product.

Wang Targeted inhibition of disheveled PDZ domain via NSC668036 depresses fibrotic process. Exp.Cell Res. 2015 PMID: 25445788
Shan Identification of a specific inhibitor of the dishevelled PDZ domain. Biochemistry 2005 PMID: 16300398