NSC 636819
Tocris Bioscience, part of Bio-Techne | Catalog # 5287
KDM4A/KDM4B inhibitor
Product Description
NSC 636819 is a KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. Also negatively regulates androgen-responsive genes.Product Specifications
Molecular Weight
510.15
Formula
C22H12Cl4N2O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
CAS Number
1618672-71-1
PubChem ID
6288112
InChI Key
YYZPXBXVBQSBDG-IJIVKGSJSA-N
SMILES
ClC(C=C1)=C(Cl)C=C1/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC=C(Cl)C(Cl)=C3)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.1 | 10 |
Preparing Stock Solutions
for NSC 636819
The following data is based on the product molecular weight 510.15
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.60 mL | 98.01 mL | 196.02 mL |
| 0.5 mM | 3.92 mL | 19.60 mL | 39.20 mL |
| 1 mM | 1.96 mL | 9.80 mL | 19.60 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.92 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chu KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J.Med.Chem. 2014 PMID: 24971742
Product Specific Notices for NSC 636819
For research use only
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