NS 383

Name: NS 383
Brand: Tocris Bioscience
SKU: 5927

Tocris Bioscience, part of Bio-Techne | Catalog # 5927

Citations (4)

COA / SDS

ASIC blocker; active in vivo

Discontinued Product

5927 has been discontinued. View all Acid-sensing Ion Channel Blockers products.

Key Product Details

Description:	ASIC blocker; active in vivo
Chemical Name:	8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime
Molecular Weight:	321.37

View Full Technical Details for NS 383

Technical Data
Citations

Biological Activity for NS 383

NS 383 is an ASIC blocker (IC₅₀ values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC₅₀ value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC₅₀ values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC_5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.

Technical Data for NS 383

M. Wt	321.37
Formula	C₁₉H₁₉N₃O₂
Storage	Store at -20°C
CAS Number	309711-59-9
PubChem ID	135418391
InChi Key	CHVQAXYXYIDNDC-UHFFFAOYSA-N
Smiles	CCN1CCC2=C(C3=C(/C(C(N3)=O)=N\O)C=C2C4=CC=CC=C4)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NS 383

References are publications that support the biological activity of the product.

Munro NS383 Selectively inhibits acid-sensing ion channels containing 1a and 3 subunits to reverse inflammatory and neuropathic hyperalgesia in rats. CNS Neurosci.Ther. 2016 PMID: 26663905

NS 383

Tocris Bioscience, part of Bio-Techne | Catalog # 5927

Key Product Details

Biological Activity for NS 383

Technical Data for NS 383

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for NS 383

Product Documents for NS 383

COA

Certificate of Analysis

SDS

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