NS 2028

Tocris Bioscience, part of Bio-Techne | Catalog # 4517

Potent soluble guanylyl cyclase (sGC) inhibitor
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Key Product Details

Description

Potent soluble guanylyl cyclase (sGC) inhibitor

View all Guanylyl Cyclase Inhibitors »

Product Description

NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

Product Specifications

Molecular Weight

269.05

Formula

C9H5BrN2O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one

CAS Number

204326-43-2

PubChem ID

4551

InChI Key

MUDRLQRJCGJJTB-UHFFFAOYSA-N

SMILES

BrC1=CC=C(OCC(N23)=NOC3=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.91 100
Ethanol 5.38 20

Preparing Stock Solutions for NS 2028

The following data is based on the product molecular weight 269.05

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.72 mL 18.58 mL 37.17 mL
5 mM 0.74 mL 3.72 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.72 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NS 2028

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 2028

For research use only

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