NS 1619

Name: NS 1619
Brand: Tocris Bioscience
SKU: 3804
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3804

(2)

Citations (17)

COA / SDS

KCa1.1 (BK) channel activator

Key Product Details

Description:	K_Ca1.1 (BK) channel activator
Chemical Name:	1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	362.23

View Full Technical Details for NS 1619

Technical Data
Citations / Reviews (2)

Biological Activity for NS 1619

NS 1619 is a large-conductance Ca²⁺-activated potassium (BK_Ca, K_Ca1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC₅₀ = 3.6 μM).

Technical Data for NS 1619

M. Wt	362.23
Formula	C₁₅H₈F₆N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	153587-01-0
PubChem ID	4552
InChi Key	YLFMCMWKHSDUCT-UHFFFAOYSA-N
Smiles	O=C2NC1=CC(C(F)(F)F)=CC=C1N2C3=CC(C(F)(F)F)=CC=C3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 1619

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.22	100
	ethanol	36.22	100

Preparing Stock Solutions for NS 1619

The following data is based on the product molecular weight 362.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.80 mL	27.61 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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Reconstitution Calculator

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References for NS 1619

References are publications that support the biological activity of the product.

Debska Large-conductance K⁺ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem.Pharmacol. 2003 PMID: 12781334
Han The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochem.Biophys.Res.Comm.
Olesen Selective activation of Ca(2+)-dependent K⁺ channels by novel benzimidazolone. Eur.J.Pharmacol. 1994 PMID: 8137869