NS 11021

Tocris Bioscience, part of Bio-Techne | Catalog # 4788

KCa1.1 (BK) channel activator
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Key Product Details

Description

KCa1.1 (BK) channel activator

View all Ca2+-Activated Potassium Channel Activators »

Product Description

NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.

Product Specifications

Molecular Weight

511.24

Formula

C16H9BrF6N6S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea

CAS Number

956014-19-0

PubChem ID

24825677

InChI Key

MDKAFDIKYQMOMF-UHFFFAOYSA-N

SMILES

BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.12 100
Ethanol 51.12 100

Preparing Stock Solutions for NS 11021

The following data is based on the product molecular weight 511.24

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.78 mL 19.56 mL
5 mM 0.39 mL 1.96 mL 3.91 mL
10 mM 0.20 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.20 mL 0.39 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for NS 11021

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 11021

For research use only

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