NPY 5RA972
Tocris Bioscience, part of Bio-Techne | Catalog # 3677
Potent and selective NPY Y5 antagonist
Discontinued Product
3677 has been discontinued.
View all NPY Receptor Antagonists products.
Key Product Details
Description
Potent and selective NPY Y5 antagonist
Product Description
Potent and selective neuropeptide Y Y5 receptor antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.Product Specifications
Molecular Weight
351.44
Formula
C21H25N3O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide
CAS Number
439861-56-0
PubChem ID
9884833
InChI Key
ZNFMHLDBJPAFEQ-UHFFFAOYSA-N
SMILES
CC1=C(NC(N4CCOCC4)=O)C=CC3=C1C2=CC=CC=C2N3C(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.14 | 100 |
Preparing Stock Solutions
for NPY 5RA972
The following data is based on the product molecular weight 351.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.23 mL | 28.45 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Turnbull Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 2002 PMID: 12145156
- Morris Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors. Eur.J.Neurosci. 2007 PMID: 17331209
- Block Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J.Med.Chem. 2002 PMID: 12139462
Product Specific Notices for NPY 5RA972
For research use only
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