NPY 5RA972

Name: NPY 5RA972
Brand: Tocris Bioscience
SKU: 3677

Tocris Bioscience, part of Bio-Techne | Catalog # 3677

COA / SDS

Potent and selective NPY Y5 antagonist

Discontinued Product

3677 has been discontinued. View all NPY Receptor Antagonists products.

Key Product Details

Description:	Potent and selective NPY Y₅ antagonist
Chemical Name:	N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	351.44

View Full Technical Details for NPY 5RA972

Technical Data
Citations

Biological Activity for NPY 5RA972

Potent and selective neuropeptide Y Y₅ receptor antagonist (IC₅₀ values are 3.1, >10000, >10000 and >10000 nM for Y₅, Y₁, Y₂ and Y₄ receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant.

Technical Data for NPY 5RA972

M. Wt	351.44
Formula	C₂₁H₂₅N₃O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	439861-56-0
PubChem ID	9884833
InChi Key	ZNFMHLDBJPAFEQ-UHFFFAOYSA-N
Smiles	CC1=C(NC(N4CCOCC4)=O)C=CC3=C1C2=CC=CC=C2N3C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NPY 5RA972

References are publications that support the biological activity of the product.

Turnbull Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes 2002 PMID: 12145156
Morris Neuropeptide Y suppresses absence seizures in a genetic model primarily through effects on Y receptors. Eur.J.Neurosci. 2007 PMID: 17331209
Block Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J.Med.Chem. 2002 PMID: 12139462

NPY 5RA972

Tocris Bioscience, part of Bio-Techne | Catalog # 3677

Key Product Details

Biological Activity for NPY 5RA972

Technical Data for NPY 5RA972

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for NPY 5RA972

Product Documents for NPY 5RA972

COA

Certificate of Analysis

SDS

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