NPPB
Tocris Bioscience, part of Bio-Techne | Catalog # 0593
Inhibits calcium-sensitive chloride currents
Key Product Details
Description
Inhibits calcium-sensitive chloride currents
Product Description
Inhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist.Product Specifications
Molecular Weight
300.31
Formula
C16H16N2O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
5-Nitro-2-(3-phenylpropylamino)benzoic acid
CAS Number
107254-86-4
PubChem ID
4549
InChI Key
WBSMIPAMAXNXFS-UHFFFAOYSA-N
SMILES
OC(=O)C1=CC(=CC=C1NCCCC1=CC=CC=C1)[N+]([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.03 | 100 | |
| Ethanol | 6.01 | 20 |
Preparing Stock Solutions
for NPPB
The following data is based on the product molecular weight 300.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.65 mL | 33.30 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wangemann Cl--channel blockers in the thick ascending limb of the loop of Henle. Structure-activity relationship. Pflugers Arch. 1986 PMID: 2434915
- Kirkup Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein. Br.J.Pharmacol. 1996 PMID: 8825360
- Taniguchi 5-nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist Pharmacology 2008 PMID: 18818509
- Keeling Effects of NPPB (5-nitro-1-(3-phenylpropylamino)benzoic acid on chloride transport in intestinal tissues and the T84 cell line. Biochim.Biophys.Acta 1991 PMID: 1720331
Product Specific Notices for NPPB
For research use only
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