nor-Binaltorphimine dihydrochloride

Name: nor -Binaltorphimine dihydrochloride
Brand: Tocris Bioscience
SKU: 0347
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0347

(3)

Citations (13)

COA / SDS

Selective κ antagonist

Discontinued Product

0347 has been discontinued. View all Kappa Opioid Receptor Antagonists products.

Key Product Details

Description:	Selective κ antagonist
Alternative Names:	nor-BNI,Norbinaltorphimine
Chemical Name:	17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	734.72

View Full Technical Details for nor-Binaltorphimine dihydrochloride

Technical Data
Citations / Reviews (3)

Biological Activity for nor-Binaltorphimine dihydrochloride

nor-Binaltorphimine dihydrochloride is a selective κ-opioid receptor antagonist.

Licensing Information

Sold with the permission of the University of Minnesota

Technical Data for nor-Binaltorphimine dihydrochloride

M. Wt	734.72
Formula	C₄₀H₄₃N₃O₆.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	113158-34-2
PubChem ID	11957626
InChi Key	JOJPJLHRMGPDPV-LZQROVCBSA-N
Smiles	Cl.Cl.OC1=CC=C2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](OC1=C24)C1=C(C[C@@]35O)C2=C(N1)[C@@H]1OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@H](C4)[C@]1(O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for nor-Binaltorphimine dihydrochloride

References are publications that support the biological activity of the product.

Feng Nor-binaltorphimine precipitates withdrawal and excitatory amino acid release in the locus ceruleus of butorphanol- but not morphine-dependent rats. J.Pharmacol.Exp.Ther. 1997 PMID: 9353416
Portoghese Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17'-basic group in the interaction with a putative address subsite on the κ opioid receptor. J.Med.Chem. 1994 PMID: 8182708
Blake Differential agonist regulation of the human κ-opioid receptor. J.Neurochem. 1997 PMID: 9109509