Nociceptin

Name: Nociceptin
Brand: Tocris Bioscience
SKU: 0910

Tocris Bioscience, part of Bio-Techne | Catalog # 0910

Citations (69)

COA / SDS

Endogenous NOP agonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous NOP agonist

Alternative Names

Orphanin FQ

View all NOP Receptor Agonists »

Product Description

Nociceptin is an endogenous ligand for the NOP opioid receptor (pK_i = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pK_i < 6).

Product Specifications

Molecular Weight

1809.00

Formula

C₇₉H₁₂₉N₂₇O₂₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

170713-75-4

PubChem ID

16131448

InChI Key

PULGYDLMFSFVBL-SMFNREODSA-N

SMILES

[H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Meunier Isolation and structure of the endogenous agonist of opioid receptor-like ORL₁ receptor. Nature 1995 PMID: 7566152
Henderson and McKnight The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS 1997 PMID: 9277133
Reinscheid Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science 1995 PMID: 7481766
Guerrini Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A. Peptides 2000 PMID: 10998526