NK 252
Tocris Bioscience, part of Bio-Techne | Catalog # 5293
Nrf2 activator
Product Description
NK 252 is an Nrf2 activator; interacts with the Nrf2-binding site of Keap1. Downregulates the expression of fibrogenic genes and increases antioxidant effects in NASH rat models of liver disease.Product Specifications
Molecular Weight
285.26
Formula
C13H11N5O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
CAS Number
1414963-82-8
PubChem ID
71618700
InChI Key
FNSCFQXZZNCDAI-UHFFFAOYSA-N
SMILES
O=C(NC2=NN=C(C3=CC=CO3)O2)NCC1=CC=CC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 28.53 | 100 | |
| DMSO | 28.53 | 100 |
Preparing Stock Solutions
for NK 252
The following data is based on the product molecular weight 285.26
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.51 mL | 17.53 mL | 35.06 mL |
| 5 mM | 0.70 mL | 3.51 mL | 7.01 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.51 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shimozono Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol.Pharmacol. 2013 PMID: 23592516
Product Specific Notices for NK 252
For research use only
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