Nicotinamide Riboside
Tocris Bioscience, part of Bio-Techne | Catalog # 6018
NAD+ precursor; substrate for nicotinamide riboside kinases
Key Product Details
Description
NAD+ precursor; substrate for nicotinamide riboside kinases
Product Description
Nicotinamide Riboside is an NAD+ precursor. It is a substrate for nicotinamide riboside kinases (NRK1/2). Nicotinamide Riboside shows neuroprotective effects in a mouse model of type 2 diabetes and improves mitochondrial function in muscle stem cells in aged mice. The compound also corrects non-alchoholic fatty liver disease phenotype induced by NAD+ deficiency or high-fat diet in mice. Orally bioavailable.Product Specifications
Molecular Weight
290.70
Formula
C11H15ClN2O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium chloride
CAS Number
23111-00-4
PubChem ID
90480033
InChI Key
YABIFCKURFRPPO-IVOJBTPCSA-N
SMILES
NC(C1=C[N+]([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=CC=C1)=O.[Cl-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.07 | 100 | |
| DMSO | 29.07 | 100 |
Preparing Stock Solutions
for Nicotinamide Riboside
The following data is based on the product molecular weight 290.70
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.44 mL | 17.20 mL | 34.40 mL |
| 5 mM | 0.69 mL | 3.44 mL | 6.88 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.44 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Trammell Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice. Sci.Rep. 2016 PMID: 27230286
- Zhou Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br.J.Pharmacol. 2016 PMID: 27174364
- Zhang NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 2016 PMID: 27127236
Product Specific Notices for Nicotinamide Riboside
For research use only
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