NGI 1

Name: NGI 1
Brand: Tocris Bioscience
SKU: 6652

Tocris Bioscience, part of Bio-Techne | Catalog # 6652

Citations (4)

COA / SDS

Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral

Key Product Details

Description:	Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral
Chemical Name:	5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	394.51

View Full Technical Details for NGI 1

Technical Data
Citations

Biological Activity for NGI 1

NGI 1 is an oligosaccharyltransferase (OST) inhibitor; anti-flaviviral. Inhibits dengue, Zika, West Nile, and yellow fever viruses by blocking viral RNA replication (EC₅₀ values are 0.85 and 2.2 μM for DENV and ZIKV inhibition, respectively). Selectively arrests proliferation of non-small-cell lung cancer cells that are dependent on EGFR or FGFR for survival.

Compound Libraries for NGI 1

NGI 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NGI 1

M. Wt	394.51
Formula	C₁₇H₂₂N₄O₃S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	790702-57-7
PubChem ID	2519269
InChi Key	QPKGRLIYJGBKJL-UHFFFAOYSA-N
Smiles	CN(S(=O)(C1=CC(C(NC2=NC=C(S2)C)=O)=C(N3CCCC3)C=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NGI 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.45	100

Preparing Stock Solutions for NGI 1

The following data is based on the product molecular weight 394.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.67 mL	25.35 mL
5 mM	0.51 mL	2.53 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for NGI 1

References are publications that support the biological activity of the product.

Lopez-Sambrooks Oligosaccharyltransferase inhibition overcomes therapeutic resistance to EGFR tyrosine kinase inhibitors. Cancer Res. 2018 PMID: 30026325
Lopez-Sambrooks Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nat.Chem.Biol. 2016 PMID: 27694802
Puschnik A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity. Cell Rep. 2017 PMID: 29241533