NGB 2904

Tocris Bioscience, part of Bio-Techne | Catalog # 2635

Potent and selective D3 antagonist
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Key Product Details

Description

Potent and selective D3 antagonist

View all Dopamine D3 Receptor Antagonists »

Product Description

NGB 2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.

Product Specifications

Molecular Weight

530.92

Formula

C28H29Cl2N3O.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide

CAS Number

189061-11-8

PubChem ID

19366304

InChI Key

PFIWYJNBKGCVFM-UHFFFAOYSA-N

SMILES

Cl.ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNC(=O)C2=CC=C3C(CC4=CC=CC=C34)=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.27 25
Ethanol 2.65 5

Preparing Stock Solutions for NGB 2904

The following data is based on the product molecular weight 530.92

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 7.53 mL 37.67 mL 75.34 mL
1.25 mM 1.51 mL 7.53 mL 15.07 mL
2.5 mM 0.75 mL 3.77 mL 7.53 mL
12.5 mM 0.15 mL 0.75 mL 1.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NGB 2904

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NGB 2904

For research use only

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